Archives of Epilepsy
ORIGINAL ARTICLE

The Role of Add-On Lacosamide Therapy in the Treatment of Focal Onset Epilepsy

1.

Department of Neurology, Gülhane Training and Research Hospital, Ankara, Turkey

2.

Department of Neurology, Baskent University Faculty of Medicine, Adana Training and Research Center, Adana, Turkey

3.

Department Of Neurology, Tobb Economics And Technology University Faculty of Medicine, Ankara, Turkey

4.

Department of Physiotherapy and Rehabilitation, Eastern Mediterranean University Faculty of Health Sciences, Cyprus

Archives of Epilepsy 2017; 23: 103-108
DOI: 10.14744/epilepsi.2017.07078
Read: 177 Downloads: 204 Published: 20 December 2021

Objectives: The aim of this study was to retrospectively evaluate the efficacy and safety of lacosamide (200-300-400 mg/day) as adjunct treatment in patients with uncontrolled focal-onset seizures taking 2 or more antiepileptic drugs (AED).

Methods: The medical records of patients with uncontrolled focal epilepsy who received lacosamide as add-on therapy for at least 6 months was reviewed retrospectively. The demographic data, the doses of lacosamide, concomitant AED therapy, and seizure activity in first and sixth months were analysed.

Results: A total of 83 patients were evaluated. The mean percent reduction in seizure frequency per month was 38.98% in the first month and 33.22% in the sixth month. In all, 53% of the patients had a decrease in seizures of 50% or more in the first month, and 47% saw a similar decrease in the sixth month . The percentage of those taking a sodium channel blocking AED in addition to lacosamide was 97.6%. Dose-related adverse events reported included dizziness, nausea, diplopia, gastroenterological side effects, headache, itchy skin, and blurred vision. It was determined that all of the patients with drug-related side effects were taking a sodium channel blocking AED concomitantly with lacosamide.

Conclusion: Adjuvant treatment with lacosamide reduced seizure frequency for patients with uncontrolled focal-onset seizures.


Fokal Başlangıçlı Epilepside Lakozamidin Ek Tedavideki Yeri

Amaç: İki veya daha fazla antiepileptik ilaç (AEİ) kullanan ve nöbetleri durmayan fokal başlangıçlı epilepsi hastalarında lakozamidin 200–300– 400 mg/gün dozlarda ek tedavi olarak kullanılmasının etkinliği ve güvenilirliğini geriye dönük olarak incelenmesi amaçlandı.

Gereç ve Yöntem: Nöbetleri durmayan ve ek tedavi olarak en az altı ay boyunca lakozamid kullanan fokal başlangıçlı nöbetleri olan hastaların tıbbi kayıtları geriye dönük olarak incelendi. Demografik veriler, lakozamid dozu, birlikte kullandığı AEİ tedavisi ve birinci ve altıncı aylardaki nöbet aktivitesi incelendi.

Bulgular: Toplam 83 hasta değerlendirildi. Nöbet sıklığındaki ortalama azalma birinci ayda %38.88, altıncı ayda %33.22 ve tedaviye %50 yanıt oranı birinci ayda %53, altıncı ayda %47 olarak bulundu. Lakozamid ile birlikte kullanılan ve sodyum kanalı üzerinden etki eden AEİ oranı %97.6 olarak bulundu. Doza bağımlı yan etkiler sersemlik, bulantı, diplopi, gastrointestinal yan etkiler, baş ağrısı, kaşıntı ve görme bulanıklığı olarak bulundu. İlaç yan etkisi tespit edilen hastaların hepsinin lakozamid ile birlikte sodyum kanalı üzerinden etki eden AEİ kullandığı tespit edildi.

Sonuç: Kontrol altına alınamayan fokal başlangıçlı nöbetleri olan hastalarda ek lakozamid tedavisi nöbet sıklığını azaltmaktadır.

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EISSN 2792-0550