Archives of Epilepsy
Original Article

Evaluation of Monocyte/Lymphocyte, Neutrophil/Lymphocyte, and Platelet/Lymphocyte Ratios in Patients with Temporal Lobe Epilepsy

1.

Department of Neurology, Sivas Cumhuriyet University, Faculty of Medicine, Sivas, Turkey

Archives of Epilepsy 2022; 28: 29-34
DOI: 10.54614/ArchEpilepsy.2022.56933
Read: 74 Downloads: 36 Published: 29 March 2022

Objective: This study aimed to determine the levels of monocyte/lymphocyte, neutrophil/lymphocyte, and platelet/lymphocyte (PLR) ratios in patients with mesial temporal lobe epilepsy, which is considered to be a chronic inflammatory brain disease, by comparing with healthy individuals of similar age and gender and to reveal the role of these values in the disease process.

Methods: In our retrospective single-center study, 76 patients who were diagnosed with mesial temporal lobe epilepsy and 47 healthy volunteers of similar age and gender were included.

Results: While neutrophil/lymphocyte and monocyte/lymphocyte ratio values were statistically significantly higher in the patient group, there was no difference between the 2 groups in terms of platelet/lymphocyte ratio. It was found that the presence of mesial temporal sclerosis, febrile convulsion, or trauma, and seizure
type and frequency did not cause any changes on neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratio values. There was a positive and statistically significant correlation between disease duration and neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratio values. It was determined that values above 0.2 for monocyte/lymphocyte ratio and 1.99 for neutrophil/lymphocyte ratio can be used in the diagnosis of mesial temporal lobe epilepsy with high sensitivity and specificity.

Conclusions: Considering that patients with mesial temporal lobe epilepsy have higher monocyte/lymphocyte and neutrophil/lymphocyte ratio values and neutrophil/lymphocyte and monocyte/lymphocyte ratio values increase as the duration of the disease increases; it can be suggested that patients with mesial temporal lobe epilepsy have increased inflammatory activity compared to healthy controls, this activity continues to increase as the duration of the disease increases and contributes to the progressive process of mesial temporal lobe epilepsy.

Cite this article as: Bolayır A. Evaluation of monocyte/lymphocyte, neutrophil/lymphocyte, and platelet/lymphocyte ratios in patients with temporal lobe epilepsy. Arch Epilepsy. 2021;28(1):29-34.

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