E-ISSN: 2792-0550
The Efficacy of Topiramate in Childhood Epilepsies
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Original Article
VOLUME: 9 ISSUE: 3
P: 151-154
December 2003

The Efficacy of Topiramate in Childhood Epilepsies

Arch Epilepsy 2003;9(3):151-154
Kutluhan YILMAZ 1
Burak TATLI 2
Nur AYDINLI 3
Mine ÇALIŞKAN 4
Meral ÖZMEN 5
1. Gaziantep Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı
2. İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı
3. İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Nörolojisi Bilim Dalı
4. İstanbul Üniversitesi Çocuk Sağlığı Enstitüsü Çocuk Nörolojisi Bilim Dalı
5. Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Çocuk Nörolojisi Bilim Dalı
No information available.
No information available
Received Date: 09.07.2003
Accepted Date: 12.12.2003
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ABSTRACT

Objectives:

We evaluated the clinical results of topiramate in epileptic children.

Patients and Methods:

The efficacy of topiramate was retrospectively aşeşed in 88 children (39 girls, 49 boys; mean age 8.3 years; range 4 months to 18 years). Most of the patients had symptomatic (n=64) and/or refractory epilepsy (n=73) to at least three antiepileptic drugs. Response to treatment was evaluated as complete disappearance of seizures or partial decrease of more than 50%. Daily initial and final doses ranged from 0.6 to 1.1 mg/kg and 3.2 to 15 mg/kg, respectively, with a mean duration of 11 months (range 6 to 38 months).

Results:

Forty-eight patients (57%) responded to topiramate treatment, 14 of whom were seizure-free. Response rates were as follows: partial epilepsy 66% (39/59), generalized epilepsy 41.7% (5/12), and epileptic syndromes 30% (4/13). Response was 66% in partial seizures (38/58) and 48.4 in generalized seizures (15/31). Treatment was discontinued because of somnolence in four patients, increase in the frequency of seizures in three patients, and hyperthermia in one patient. Adverse effects were anorexia (n=14), weight loş (n=11), difficulty in concentration (n=8), somnolence (n=7), deterioration in speech (n=6), and fever (n=3).

Conclusion: Topiramate seems to be a safe and effective antiepileptic drug; however, it should be used considering its special side effect profile.

Keywords:
Anticonvulsants/therapeutic use/adverse eff e c t s;child; epilepsy/drug therapy; epilepsies, partial/drug therapy;fructose/therapeutic use/analogs & derivatives; treatment outcome.