ABSTRACT

There were some experimental and clinical evidence that inflammation in the brain is likely to predispose epileptogenesis. Also, it is thought to be that oxidative stress can play a role in epilepsy. Both laboratory and clinical studies have demonstrated the antiinflammatory-antioxidant properties of doxycycline. We aimed to highlight the anticonvulsant action of doxycycline based on clinical, laboratory and EEG findings in animal models.

36 rats were randomly divided in two groups. Group A for EEG recordings and Group B for behavioral assesment. 35 mg/kg pentylene tetrazole (PTZ) used for EEG recording and 70 mg/kg PTZ used for behavioral evaulations. For behavioral evaluations we assessed first myoclonic jerk time (FMJ) and Racine convulsion scores (RCS).

The groups were evaluated according to EEG records and severety of seizures. It was found to be doxcycyline is effective both on the time of the first myoclonic jerk’ (FMJ) latency and Racine convulsion scale (RCS) scores. Besides, doxcycyline significantly decreased to the percentage of spikes on electroencephalography (EEG) records. Also In current study, it was detected that Malone dialdehit (MDA) levels decreased and superoxide dismutase (SOD) activity increased in doxcycyline-treated groups.

In our study, we evaluated that the anticonvulsant effects of doxycycline showed a dose dependent protective effect against PTZ-induced seizures in rats by its anti-inflammatory and neuroprotective properties.

Keywords: Doxcycyline, malonedialdehit, pentylenetetrazole, superoxide dismutase