E-ISSN: 2792-0550
Locotomor Activity, Leaming and Memory in VVAG/Rij Rats with Absence Epilepsy
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Current Issue: 2022, Volume 32, Issue 3
VOLUME: 14 ISSUE: 3
P: 167-175
December 2008

Locotomor Activity, Leaming and Memory in VVAG/Rij Rats with Absence Epilepsy

Arch Epilepsy 2008;14(3):167-175
Ayşe Karson 1
Filiz Onat 2
Fuat Balcı 3
Nurbay Ateş 1
1. Kocaeli Üniversitesi Fizyoloji Anabilim Dalı
2. Marmara Üniversitesi Tıp Fakültesi Farmakoloji Anabilim Dalı
3. Department Of Psychology And Rutgers Center For Cognitive Science, Rutgers University, New Brunswick, Nj
No information available.
No information available
Accepted Date: 12.02.2009
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ABSTRACT

Objectives:

The aim of this study was to evaluate the behavioral characteristics of WAG/Rij rats, a genetic model for absence epilepsy.

Materials and methods:

The performance of WAG/Rij rats in passive avoidance, Morris-water maze and open-field tests were compared with the VVistar rats (control group).

Results:

Passive avoidance and rota-rod performance did not differ between the two groups. VVAG/Rij rats exhibited longer escape latencies on the first day of training in Morris water-maze, however, this difference disappeared with further training and during the probe day (without the platform). VVAG/Rij rats exhibited increased locomotor activity in the open-field test.

Discussion:

Results are discussed with respect to known behavioral and cognitive deficits that characterize patients with absence epilepsy.

Keywords:
Absence epilepsy, VVAG/Rij, rat, behavior, open field, passive avoidance, water maze, memory, locomotion