ABSTRACT

Contraception is an important consideration for women with epilepsy. The pharmacokinetic interactions between antiepileptic drugs and oral contraceptives are biderectional. Steroid hormones and enzyme-inducing antiepileptic drugs are substrates for the cytochrome P450 enzyme system. As a result, the concomitant use of hormonal contraceptives and antiepileptic drugs may pose a risk for unexpected pregnancy and seizures. Intrauterine devices and barrier methods are appropriate to recommend for use in women using enzyme-inducing medications. Depot medroxyprogesterone acetate injections appear to be effective; however, they may not be the first choice due to serious effects. Oral contraceptives significantly increase the metabolism of lamotrigine. Therefore, women with epilepsy taking lamotrigine need to be monitored carefully.

Keywords: Antiepileptic drugs, epilepsy, hormonal contraceptives