ABSTRACT

Epilepsy is a serious neurologic disease characterized by spontaneous seizures. During epileptic conditions, the antioxidant system is affected in both the brain and other tissues/organs. Pentylenetetrazol is used to induce animal-sourced epilepsy models. S-methyl methionine sulfonium chloride is a novel antioxidant that ameliorates much toxicity via its property. This study aimed to investigate the protective effect of S-methyl methionine sulfonium chloride on penty lenet etraz ol-in duced seizures lens injury.

Male Sprague–Dawley rats were divided into 4 groups. The control group received 0.9% NaCl per day intraperitoneally for 1 week, S-methyl methionine sulfonium chloride group was given S-methyl methionine sulfonium chloride at a dose of 50 mg/kg per day orally for 1 week, pentylenetetrazol group was given 60 mg/kg of pentylenetetrazol as a single dose, and pentylenetetrazol + S-methyl methionine sulfonium chloride group treatments were administered at the same dose and time. At the end of the experiment, all the animals were sacrificed, and lenses were taken.

Lens glutathione and total antioxidant capacity were decreased, while advanced oxidized protein products, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, gluta thion e-S-t ransf erase , aldose reductase, sorbitol dehydrogenase, and carbonic anhydrase were increased in pentylenetetrazol group. The administration of S-methyl methionine sulfonium chloride reversed these parameters.

S-methyl methionine sulfonium chloride ameliorated penty lenet etraz ol-in duced lens injury through its unique antioxidant activity.

Keywords: Lens, s-methyl methionine sulfonium chloride, penty lente trazo l-ind uced seizures