ABSTRACT

Objective:

Epilepsy is a serious neurologic disease characterized by spontaneous seizures. During epileptic conditions, the antioxidant system is affected in both the brain and other tissues/organs. Pentylenetetrazol is used to induce animal-sourced epilepsy models. S-methyl methionine sulfonium chloride is a novel antioxidant that ameliorates much toxicity via its property. This study aimed to investigate the protective effect of S-methyl methionine sulfonium chloride on penty lenet etraz ol-in duced seizures lens injury.

Methods:

Male Sprague–Dawley rats were divided into 4 groups. The control group received 0.9% NaCl per day intraperitoneally for 1 week, S-methyl methionine sulfonium chloride group was given S-methyl methionine sulfonium chloride at a dose of 50 mg/kg per day orally for 1 week, pentylenetetrazol group was given 60 mg/kg of pentylenetetrazol as a single dose, and pentylenetetrazol + S-methyl methionine sulfonium chloride group treatments were administered at the same dose and time. At the end of the experiment, all the animals were sacrificed, and lenses were taken.

Results:

Lens glutathione and total antioxidant capacity were decreased, while advanced oxidized protein products, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, gluta thion e-S-t ransf erase , aldose reductase, sorbitol dehydrogenase, and carbonic anhydrase were increased in pentylenetetrazol group. The administration of S-methyl methionine sulfonium chloride reversed these parameters.

Conclusion:

S-methyl methionine sulfonium chloride ameliorated penty lenet etraz ol-in duced lens injury through its unique antioxidant activity.