ABSTRACT

We evaluated the effect of sulbutiamine on acute pentylenetetrazole- and maximal electroshock-induced seizure models in mice.

We used male four-week Swiş albino mice (20-25 gr). The animals were kept under standardized light at a constant temperature and were fed with food and tap water. Sulbutiamine was intraperitoneally injected to 66 mice in its hydrochloride form to three groups at three diverse doses of 50, 100, and 150 mg/kg, respectively, for three days. Thirty control mice received 0.9% saline solution for the same period. At the end of three days, pentylenetetrazole- and maximal electroshock-induced seizure models were performed, during which seizure mortality, intensity, and latency were observed in the form e r, and seizure rates and mortality were observed in the latter.

Compared with controls, all doses of sulbutiamine significantly increased the intensity of seizures in the pentylenetetrazole model (p<0.01). However, it did not exert any significant effect on seizure rates and mortality in the maximal electroshock-administered mice.

Sulbutiamine has an excitatory eff e c t on pentylenetetrazole-induced seizure intensity.

Keywords: Disease models, animal, electroshock, epilepsy/drug therapy, mice, pentylenetetrazole, thiamine/ analogs & derivatives