Seizure Induced by Extended-Release Bupropion Used for Smoking Cessation at Early Term and Therapeutic Dose
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Case Report

Seizure Induced by Extended-Release Bupropion Used for Smoking Cessation at Early Term and Therapeutic Dose

Arch Epilepsy 2018;24(3):127-129 DOI: 10.14744/epilepsi.2018.04796
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Abstract

Bupropion inhibits reuptakes of dopamine and noradrenaline. Since it is also a nicotine receptor antagonist, it acts as a drug used for smoking cessation. Bupropion is commonly preferred because of no side effects on weight, sexual function, and the lack of sedative effect. Immediate and sustained-release bupropion forms may trigger seizure activity. In the present article, we report a case of a 30-year-old man presenting with generalized tonic clonic seizures induced by extended-release bupropion. We also emphasized that extended-release bupropion, which is commonly used for smoking cessation therapy, may cause seizure at early term and therapeutic dose.

Keywords: Extended-release bupropion, seizure, smoking cessation treatment