Intracranial lipomas are regarded as congenital malformations of the meninx primitiva. Here we present two patients with pericallosal lipomas extending to the thalamus. They had generalized tonic–clonic seizures. Electroencephalograms showed generalized spike-wave discharges. It is known that the thalamus is important in the formation of sleep spindles and spike-wave discharges. Thalamic involvement by lipomas may play a role in the generation of generalized spike-wave discharges and epileptogenesis in these patients.

Keywords: Lipoma, seizures, spike-wave discharges, thalamus