There are several reasons to change the drugs in epilepsy patients such as inadequate seizure control, adverse effects which cannot be tolerated, pregnancy, comorbid disease, etc. Difficulty of finding the drug is another rare reason for treatment change, even if the seizures are well controlled. In this article, we presented and discussed appropriate approaches for changing treatment in three different epileptic patients who have good seizure control with barbexaclone until discontinuation.

Keywords: Barbexaclone, phenobarbital, epilepsy, treatment