Patients receiving phenytoin may develop benign lymphoid hyperplasia, pseudolymphoma, pseudo-pseudolymphoma, or rarely malignant lymphoma. A 76-year-old man who had been receiving phenytoin 300 mg/day for 25 years developed left axillary lymphadenopathy. A biopsy from the lesion revealed Hodgkin’s lymphoma. In this report, the patient’s clinical and histopathological symptoms and signs are presented and the association between phenytoin use and lymphoid pathologies is discussed.

Keywords: Epilepsy, tonic-clonic/drug therapy, Hodgkin disease, lymphoma/chemically induced, phenytoin/ adverse effects